IntroductionCases of cytomegalovirus gastrointestinal disease are mostly apparent at immunocompromised patients (1). The esophagus is the second most common site after colon, most frequently presenting as an epigastric pain or without symptoms (2). Until now, there were only few cases described in young, immunocompetent patients (3,4). In our study we present the cytomegalovirus esophagitis in a 21 year old, immunocompetent male patient being the youngest case ever described according to searched literature.