Objective: To evaluate the efficacy and safety of misoprostol vaginal tablet (25ug) for induction of labor in term pregnancy for cervical ripening. Methods: Hospitalized women received misoprostol vaginal tablet(25ug) or dinoprostone pessary(10mg) for induction in the last year from Chengdu Women’s and Children’s Central Hospital were retrospectively analyzed. The propensity score matching method(PSM) was used to match the two groups, and non-inferiority analysis was adopted to evaluate the efficacy and safety of misoprostol vaginal tablet (25ug) for induction of labor in term pregnancy. Results: After PSM, the two groups included 103 women respectively. The total cesarean delivery rate of misoprostol vaginal tablet was higher than dinoprostone pessary(39.8% vs 38.8%), while the vaginal delivery within 24 hours was significantly lower than dinoprostone pessary (29.0% vs 41.3%). Dinoprostone pessary was more likely to have excessive contractions during induction of labor (11.7% vs 0.9%, P=0.003), At the same time, fewer other methods of induction of labor were needed subsequently(34.9% vs 64.5%, P=0.001).The rate of meconium-stained amniotic fluid, fever, episiotomy, forceps delivery, neonatal asphyxia rate, neonatal ICU admission rate and Apgar scores were no statistical difference. No severe perineal laceration, uterine rupture and maternal and fetal death occurred between the two groups. Conclusion:The noninferiority of misoprostol vaginal tablet(25ug) to the dinoprostone pessary(10mg) for induction of labor in term could not be demonstrated. The efficacy of misoprostol vaginal tablet is inferior to dinoprostone pessary, in the other hand, the safety is better. It makes sense to choose either misoprostol vaginal tablet(25ug)or dinoprostone pessary(10mg) for pregnant women in term who need to induce after inform them of the relevant advantages and disadvantages.