The Generative Cryptographic Pattern Disruption Analysis (GCPDA) framework offers a novel approach by analyzing cryptographic patterns to identify malicious activities. Through comprehensive evaluations, the framework demonstrated detection accuracies exceeding 95% across various ransomware families, including WannaCry, Locky, CryptoLocker, Petya, and Cerber. Comparative analyses revealed that GCPDA outperforms traditional detection methods, achieving a detection accuracy of 97.0% with a false positive rate of 2.5%. The framework maintained low false positive rates across different operating systems, with slightly higher rates observed in Linux environments. Resource utilization assessments indicated moderate CPU and memory usage during peak detection activities, suggesting suitability for real-time deployment. However, a gradual decline in detection rates for successive generations of polymorphic ransomware highlights the need for continuous refinement. The GCPDA framework represents a significant advancement in ransomware detection, offering a robust and adaptable solution to the evolving threat landscape.