Co-administration of vaccines consists of separate preparations of different immunogens that are administered at the same time. This practice has been common in pediatrics for many years but generally was not an issue with adult vaccination until recently. With the advent of multiple new adult respiratory vaccines that are given seasonally, co-administration has been a topic of interest. This review primarily looked at the newest vaccines (COVID-19 and RSV) in combination with the most common adult vaccine (influenza) and found that co-administration with these and other vaccines in adults is safe, effective, and acceptable. Achieving adequate vaccine coverage among adults will require a coadministration strategy similar to the approach for the pediatric population and has been shown to increase vaccine uptake overall. The World Health Organization (WHO) and the Center for Disease Control and Prevention (CDC) recognize that vaccine coadministration is a feasible approach to reduce the impact of vaccine-preventable diseases. Clinicians will have critical role to play in boosting individual and public health by offering vaccine co-administration.