Invasive pests have spread globally at an unprecedented scale, severely threatening biodiversity and resulting in significant economic losses, emerging as a global problem. In the process of spreading, pests establish new habitats, which depend on the joint effects of natural and human factors. However, research on the mechanisms by which human factors influence the global spread of Hyphantria cunea, a quarantine pest of international concern, is still lacking. Thus, this study developed a species distribution model to explore the role of human factors in predicting the global habitat suitability for Hyphantria cunea. We also emphasize that human activities and natural environmental changes have a significant impact on the distribution of invasive species such as Hyphantria cunea. Moreover, this research identifies areas of high suitability across continents and forecasts changes in the distribution patterns of Hyphantria cunea in the future. It offers crucial insights for developing more effective global quarantine strategies and pest management policies.