Introduction:Post-infectious cerebellitis (PIC) is defined as cerebellar inflammation induced by immune-mediated mechanisms triggered by viral or bacterial infections (1). Immune-mediated pathophysiological mechanisms frequently impact the cerebellum, resulting in progressive ataxia characterized by dysmetria in both motor and cognitive functions(2). Most of the patients present to the clinics with gait ataxia often associated with limb incoordination and oculomotor ataxia (3). PIC predominantly affects young children following an infectious episode, typically a viral infection, with varicella being the most common cause and rarely affecting the adult population with only a handful of cases reported in the literature(4). Herein we report a rare case of PIC in a 60-year-old male who presented with severe acute ataxic syndrome and opsoclonus in the bilateral eyes without any neuroimaging findings and antibodies in serum relevant to acute cerebellar ataxia.