The use of steroids, along with chemotherapy in the management of Acute Myeloid Leukemia (AML), is not a part of any standard regimen. Studies from various sources claimed diverse opinions about its role in AML. Based on the case reports of two children with AML, we have shown how steroids (Prednisolone and Dexamethasone) in a case of AML-M7 with RAM phenotype helped in progression and unmasking the myeloid blasts whilst causing cytoreduction and tumor lysis in another case of non-promyelocytic AML who presented with hyperleucocytosis. We hereby present two such cases with contrasting findings to understand the role of steroids in AML.