Background: In recent years, digital thoracic drainage systems have been introduced. Limited studies address the benefits and risks in pediatric patients. We compared analog and digital systems using a high-fidelity 3D-printed phantom. Methods: Direct measurements as well as measurements on a 3D-printed phantom were conducted employing a digital and analog system for different suction pressures (-1 to -20 cmH 2O). The impact of a siphon and automatic flushes of the digital system were studied. Results: At pressure settings of -20 and -10 cmH 2O, direct and phantom measurements yielded significantly different results for the digital compared to the analog system. Set pressures below -10 cmH 2O in the analog drainage system were unreliable. For the digital system, the majority of measured points fell within the chosen settings. There were statistical outliers up to -30 cmH 2O attributed to the regular flushing performed by the system. Conclusion: This is the first experimental study objectifying the suitability of digital drainage systems for the pediatric and neonatal population. Our phantom produced accurate results where tests on patients are not possible. At suction pressures of -20 and -10 cmH 2O the digital and the analog drainage system yield satisfactory results. The digital system was able to maintain pressures as low as -5 cmH 2O. The analog drainage system is less flexible but remains a reliable tool for experienced users. The digital drainage system allows more freedom and can increase patient safety by neutralizing obstructions or a siphon. The increase in suction during flushing may pose a risk for neonatal patients.