Wyoming’s demonstrated coal reserves have significant potential for hydrogen generation. This study explores the integration of natural resources and advanced technologies for hydrogen production within the state, aligning with the U.S. DOE’s Energy Earthshot initiative and the National Clean Hydrogen Strategy and Roadmap. Wyoming’s coal resources, totaling 1.4 trillion metric tons, with 46 billion metric tons classified as recoverable reserves, present a significant opportunity for hydrogen production through gasification processes. Producing hydrogen from coal, especially when coupled with carbon emission reduction technologies, is a promising near- to mid-term opportunity. This approach leverages Wyoming’s relatively inexpensive and widely available coal resources, using existing gasification technologies to meet anticipate hydrogen demand. Beyond the availability of coal resources, Wyoming’s potential as a hydrogen production hub is supported by its strategic infrastructure and water resources, essential for large-scale hydrogen generation. GIS-suitability index identifies Powder River and Green River Basins as potential viable sites for large-scale hydrogen production facilities in Wyoming State. Also, this study includes an AspenPlus simulation for Supercritical Water Gasification (SCWG) of Wyoming’s coal using a thermodynamic equillibrium model based on Gibbs Free Energy minimization based on the Peng-Robinson EOS with Boston-Mathias alpha function (PR-BM) attribute method. The results underscore Wyoming’s potential to significantly contribute to the energy transition.