jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Background and Objectives: Transcranial alternating current stimulation(tACS) has been demonstrated to improve cognition. In this study, we investigate the impact of accelerated high-definition (HD) tACS on craving and cognition in synthetic cannabinoid use disorder (SCUD). Methods: We conducted an accelerated HD-tACS on a patient with SCUD (N=1). Results: After the intervention, the patient showed reduced pathological attention bias, drug-craving, impulsivity, and risk-taking behavior. Discussion and Conclusions: Our study demonstrates the efficacy of accelerated HD-tACS in SCUD. Scientific Significance: This study provides evidence for the feasibility, safety, and efficacy of accelerated HD-tACS in a drug-dependent patient and encourages further systematic investigation.