Figure 2 - Microscopic and IHC images of specimen of first patient - (A) Microsection shows tumor cells arranged predominantly in sheets. The tumor cells are medium-sized, with hyperchromatic nuclei, inconspicuous nucleoli and scant cytoplasm. Interspersed numerous apoptotic bodies are seen [H&E, 40X]. (B) On immunohistochemistry, tumor cells are positive for FLI-1 (moderate nuclear staining). (C) Diffuse strong nuclear positivity is noted for NKX2.2 (D) Tumor cells are weakly positive for synaptophysin.