Case Series of Intracranial Central Primitive Neuroectodermal
Tumor in Two Adults Treated with Craniospinal Irradiation
Shubham Dokania, Sambit S Nanda, Ipsita Dhal, Ajay K Choubey, Ninad H
Patil, Jhansi Pattanaik, Ashutosh Mukherji
Abstract :
Ewing sarcomas (ESs) and primitive neuroectodermal tumours (PNETs)
exhibit identical genetic and histological characteristics, hence
collectively denoted as ESs/PNETs, originating from the neuroectoderm
and primarily consisting of primitive neuroectodermal cells. PNETs occur
primarily in the cerebrum. They constitute 3-5% of all paediatric brain
tumours. This case report describes two cases of intracranial central
PNET with negative IHC and chromosomal markers in adult patients treated
with craniospinal irradiation (CSI) and focal radiotherapy boost with
concurrent and adjuvant chemotherapy.
Key words : craniospinal radiotherapy, PNET, Intracranial
cancers, Medulloblastoma.