Non-classical crystallization (NCC) mechanisms in organic small molecules, characterized by nanoparticle attachment during early crystallization stages, is not completely understood. Herein we report the formation of prenucleation clusters of ibuprofen and their evaluation from amorphous to crystalline to further understand the progression of NCC mechanisms of organic small molecules. Key to differentiating NCC from classical pathways is the formation of an intermediate dense liquid phase. We employ liquid phase transmission electron microscopy (LPTEM), to understand the real-time monitoring of nanoscale nucleation events with high temporo-spatial resolution. LPTEM studies have confirmed NCC pathways showing a dense liquid phase in the range of 100 nm and their cluster orderliness in selected area electron diffraction (SAED). This study also provides insight into the antisolvent influences of prenucleation formation in NCC pathways.