Newborns with seizures usually have identifiable seizure risk factors, including hypoxic-ischemic injury, intracranial hemorrhage, intracranial infection and metabolic disturbance. Hypocalcemia is a frequent and treatable cause of [neonatal seizures](https://www.sciencedirect.com/topics/medicine-and-dentistry/infantile-spasm), with numerous possible etiologies. Here, we present the case of two newborn infants with no apparent risk factors admitted to the pediatric emergency department with seizures due to hypocalcemia. Further investigations revealed maternal hyperparathyroidism caused by parathyroid adenoma.