11pt, fleqn, a4paper, ]LegrandOrangeBook Objective: Epistaxis is a common otolaryngological presentation encountered in the clinical setting. This study compares ChatGPT’s accuracy, readability, and conciseness in addressing patient questions compared to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) Clinical Practice Guidelines [1]. Methods: Frequently asked questions (FAQs) for Patients with Nosebleed were extrapolated from the AAO-HNS Clinical Practice Guidelines [1]. ChatGPT-generated responses were compared to AAO-HNS model answers and graded by fifteen otolaryngologists for accuracy, readability, and conciseness. Results: 86.7-100% of otolaryngology consultants agreed with the accuracy of ChatGPT responses compared to 66.7-80% agreement with AAO-HNS responses. 66.7-93.3% of consultants agreed that all Chat GPT and AAO-HNS responses were easy to understand. ChatGPT responses were less concise with 6.7-40% consultant agreement, compared to 80-100% agreement with AAO-HNS responses. Conclusion: ChatGPT provided guideline-consistent epistaxis advice and appropriately encouraged specialist care but lacked conciseness. ChatGPT may serve as a useful adjunct for patients and clinicians.