Among the diseases affecting humans, dengue is the second most common mosquito-borne after malaria; according to the World Health Organization (WHO), most dengue cases occur in Asia-Pacific regions, Africa, and North/South America. This male is transmitted to humans from female mosquitoes of the Aedes genus (principally A. aegypti) through a single bite and caused by the dengue virus (DENV), a pathogen classified as Flavivirus ( Flaviviridae family). It is an acute febrile infectious disease, which may present benignly or severely. Indole nucleus has been in the spotlight due to its numerous pharmacological properties and relevance to the discovery of drug candidates. Accordingly, several reviews in the literature report the pharmacological potential of indole derivatives against multiple diseases. On this matter, this review proposal is to examine the recent four-year advances in the fields of Natural Products, Medicinal Chemistry, and Computer Aided Drug Design in the search of indole-based promising anti-dengue agents.