N6-methyladenosine RNA methylation (m6A) is the most common and abundant internal RNA modification in eukaryotic cells. It plays an important role in regulating many pathophysiological activities of eukaryotic creatures from cell metabolism to body growth and disease occurrence. There are three different kinds of m6A regulators including methyltransferases, demethylases and m6A-binding proteins which work together to complete the reversible epigenetic modification process of m6A. Bone is one of the most important organs with unreplaceable functions such as movement, load-bearing, hematopoiesis, and providing protection for other organs. Its physiological homeostasis depends on the synergistic activities of bone marrow mesenchymal stem cells (BMSCs), osteoblasts, osteoclasts and other cells. In the mean time, the treatment of bone-related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and bone tumors has always been a significant challenge. Here, we reviewed the composition of m6A as well as its regulatory mechanism in both physiological and pathological processes of bone.