Upper extremity deep vein thrombosis (UEDVT) is a complex and increasing health concern, influenced by invasive medical devices and various patient-specific factors. This review synthesizes current understanding and clinical practices in UEDVT management, highlighting the importance of anticoagulation therapy as the cornerstone of treatment. Unfractionated heparin (UFH), warfarin, and low molecular weight heparin (LMWH) are mainstays, with direct oral anticoagulants (DOACs) emerging as effective alternatives. The role of minimally invasive procedures like Percutaneous Mechanical Thrombectomy (PMT) and Catheter-Directed Thrombolysis (CDT) is emphasized for acute thrombus management. Individualized treatment strategies, considering comorbidities and patient preferences, are crucial. Future research is oriented towards personalized medicine, novel thrombolytic agents, and innovative interventional techniques to further improve outcomes in UEDVT.