This editorial focuses on the issue of data misuse which is increasingly evidenced in social media as well as some premiere scientific journals like yours. This issue is of critical importance to open science projects in general, and ABCD in particular, given the broad array of biological, behavioral and environmental information collected on this American sample of 12.000 youth and parents. ABCD data are already widely used with over 1000 publications and twice as many citations per year as expected (relative citation index based on year, field and journal). However, the adverse consequences of misuse of data, and inaccurate interpretation of emergent findings from this precedent setting study may have profound impact on disadvantaged populations and perpetuate biases and societal injustices. This editorial contains recommendations and references which may guide authors and assist reviewers alike in avoiding misleading scientific interpretations not only with use of ABCD data but other large scale data sets as well.