Despite mounting evidence of avoidable medication errors in paediatric units, effective solutions are still lacking, leading to acute and even long-term detrimental and life-threatening impacts. Aim: To develop a protocol for a proactive clinical decision support system customised to a Malaysian local paediatric population for healthcare professionals. Methods: The local drug dosing regimen based on Universiti Malaya Medical Centre (UMMC) paediatric drug consumption will be searched using a literature review from Asian studies and Malaysia Clinical Practice Guidelines. The identified drug dosing regimen and its monitoring will then be reviewed by paediatricians and pharmacists for feedback. The corroborated information will then be migrated and integrated into the online platform for incorporation into UMMC electronic medical records. The previously developed and validated medication adverse event safety signals will be incorporated into the decision support system. Results and Conclusion: The outcome of this project should proactively support clinicians working in paediatric settings and help to reduce medication errors and medication adverse event incidences in Malaysia.