11institutetext: Knowledge-based Systems and Document Processing Research Group Faculty of Computer Science Otto-von-Guericke-University Magdeburg 11email: katrin.krieger@ovgu.de Introduction: Salivary gland tumours are one of the most important diseases of the head and neck region. The aim of this study is determination of the Prevalence of salivary gland tumours in hospitals affiliated with Shiraz University of Medical Sciences from 2014 to 2020. Methods: In this cross-sectional study in Shiraz University of Medical Sciences affiliated hospitals, all the patients with salivary gland tumours who presented to the affiliated hospitals from 2014 to 2020 were selected for this study. The hospitals are located in Shiraz, Iran, which is completely ethnically Iranian. Results: Among 451 patients with salivary gland tumours, 71.4% (322 cases) had benign tumours and 28.6% (129 cases) had malignant tumours. Individuals with benign tumours had, on average, significantly lower ages at the time of diagnosis, in comparison to the malignant ones (46.2 years vs. 58.6 years, p < 0.001). The most common site of involvement was the parotid gland (89.2%). The most common benign tumour was pleomorphic adenoma. The most common malignant primary salivary gland tumour was mucoepidermoid. The majority of benign tumours (73.2%) were located in the parotid gland, while only 51% of malignant tumours were located in the parotid. Conclusion: In conclusion, we demonstrate that ethno-geographic variation might affect the distribution of SGTs across tumour sites and histopathologic types. Further research into the clinical and survival aspects of these pathologies is needed to elucidate the clinical factors and impact.