MRT is a highly malignant tumor that commonly occurs in children. Despite the current multidisciplinary treatment approach combining surgery, chemotherapy, and radiotherapy, the 3-year survival rate for affected children remains significantly low. This article presents three cases where a novel chemotherapy regimen and maintenance therapy were employed in conjunction with surgical and radiation treatments, resulting in favorable therapeutic outcomes. These findings demonstrate the feasibility and potential of the innovative personalized treatment approach utilized. Personalized treatment involves tailoring therapeutic strategies to the specific characteristics and biological behavior of individual patients. This approach holds promise in improving outcomes for children with MRT. Further research and clinical application will contribute to advancing the use of personalized treatment in the management of MRT.