Here, a chemically reactive unsteady magnetohydrodynamic Casson fluid flow in a plate with convective slip boundary conditions and activation energy is considered. To examine the implications of the model's various parameters on the temperature, concentration, and velocity profiles, graphs were produced. The model's foremost equations are solved with the aid of the MATLAB - bvp4c. The Sherwood number, the Nusselt number, and skin friction are three physical parameters of engineering relevance. To get an understanding of these factors, numerical values have been estimated for a variety of scenarios. Velocity and concentration drops as activation energy parameter improves. The tabulated statistics demonstrate that skin friction rises when the thermal and solutal Grashof numbers grow, but boosting the Biot number has the opposite effect. The current findings are compared to those found in the literature, and they are consistent.