Introduction: The transdiagnostic approach has recently emerged in psychopathology and offers a new understanding of psychiatric disorders. However, such conceptualization has mainly focused on anxiety and depression. To fill this gap, researchers recently developed the Symptomatic Transdiagnostic Test (S2T). This tool offers a broader evaluation of patients, more than the assessment of anxiety and depression. However, this scale is time-consuming, and its psychometric properties have not been assessed within a clinical population. This study aims to develop a short version of such tool and to assess its psychometric properties within a clinical sample. Method: We recruited 2 741 participants from the general population and 252 patients suffering from psychiatric disorders. They undertook the s-S2T and the Transdiagnostic Skills Scale. We assessed the factorial structure of the scale, its internal consistency, its concurrent validity and ecological validity. Results: We found good fit indexes for a B-ESEM model composed of a general psychopathological factor and 10 specific factors. We found good internal consistency and concurrent validity with the transdiagnostic skills scale. Such results were found within both general and clinical population. Finally, we demonstrated higher levels of symptoms among the clinical population than among the general population except for addictive and eating disorder symptoms. Conclusion: The s-S2T has good psychometric properties within both general population and clinical population. It can be quickly administrated and offers a broad evaluation of psychopathology for clinicians and researchers.