This paper investigates the structural behavior of transfer beams in multi-story buildings incorporating floating columns. Such buildings, common in modern architecture, often face challenges in load distribution, particularly during seismic events. Through a combination of theoretical analysis and computational modeling using ETABS, the study explores various parameters, including base shear, bending moments, shear forces, torsion, twisting on transfer beams and deflection. Utilizing advanced computational tools and design codes (ACI and UBC); a 25-storied building had been modeled to assess the effects of floating columns under different scenarios. Results indicate significant variations in structural stability, with specific configurations showing higher vulnerability. This paper emphasizes the importance of proper design and reinforcement of transfer beams to mitigate risks. The findings provide critical insights for engineers and architects aiming to enhance the safety and performance of high-rise buildings with floating columns.