Background: Prosthetic laryngoplasty (PL) is the standard surgical treatment for recurrent laryngeal neuropathy (RLN) in horses. However, postoperative complications may compromise outcomes, and the influence of breed and anaesthetic approach remains unclear. Objectives: To identify predictors of surgical success at 3 months following PL, with a focus on postoperative complications, anaesthesia type, and breed, with special interest in Iberian baroque breeds (Andalusian and Lusitano). Study design: Multicenter retrospective cohort study. Methods: Medical records from 181 horses treated at seven equine hospitals were reviewed. Variables including breed, anaesthesia type, surgical method, and postoperative complications were analysed using chi-square tests and binary logistic regression. Results: Surgical success was achieved in 79.11% of cases. Postoperative complications occurred in 33.7% of horses and were significantly associated with treatment failure. Two independent predictors of poor outcome were identified: major loss of arytenoid abduction (OR = 0.000567; p < 0.001) and surgical site infection (SSI) (OR = 0.007; p < 0.001). Breed type and anaesthetic modality were not significantly associated with outcome. The final model demonstrated excellent predictive performance (AUC = 0.978; accuracy = 96.7%). Main limitations: Multicenter retrospective study that may be affected by selection bias and variability in practices. Conclusions: Loss of arytenoid abduction and SSI are critical determinants of poor outcome following PL. These findings underscore the importance of meticulous surgical technique and strict infection control. Breed and anaesthetic approach did not influence outcome. Identification of key risk factors supports improved surgical planning, targeted prevention, and clearer prognostic communication.