Aortic valve calcification foci detachment leading to arterial embolism is very rare in clinical practice, and is occasionally caused by surgical operation and external interference. Due to the different embolization sites, clinical symptoms and imaging findings are also different, and insufficient knowledge of clinicians can easily lead to missed diagnosis and aiagnostic errors. We report a very rare emergency case in a 36-year-old patient who presented with sudden syncope for 4 hours. Echocardiography revealed severe calcification of the aortic valve and focal activity. Strong echoic lesions were also found in the distal segment of the brachiocephalic trunk, resulting in severe stenosis. We consider the loss of calcification of the aortic valve leading to insufficient blood supply to the brain and the occurrence of syncope. The patient received timely surgical treatment. Although active detachment of aortic valve calcification lesions is very rare, we also need to consider this possibility.