Proteolysis-targeting chimeras targeted protein degradation technology can achieve the degradation of specific proteins. It is to use a bifunctional small molecule to bind the target protein with E3 ubiquitin ligase and ubiquitinate it, thereby degrading the target protein through the ubiquitin-proteasome pathway. Peptide proteolysis-targeting chimeras is a peptide type proteolysis-targeting chimeras molecule developed through synthetic biology, which not only has the targeted protein degradation effect of proteolysis-targeting chimeras, but also is biologically safe. At present, peptide proteolysis-targeting chimeras is achieving significant success in precision medicine such as targeted treatment of cancer. However, it is still a blank space in the cosmetics field. If the peptide proteolysis-targeting chimeras can be used in the development of cosmetic raw materials, it will undoubtedly trigger a revolution in precision skincare. This review provides a detailed introduction to the mechanism, function, and potential enormous application value of peptide proteolysis-targeting chimeras in the development of cosmetic raw materials.