Purpose: Low-incidence but serious adverse reactions to antidepressants, such as stroke, have received close attention recently. Many patients start antidepressant treatment at a young age. However, the literature on the stroke risk associated with antidepressants in non-elderly adults remains insufficient. To delineate the stroke risk related to antidepressants among various age groups, class of antidepressants, and indications in adults. Methos: This was a cohort study using the new user approach and included adults aged 18-44 in 2018. 119,751 antidepressant users and 119,751 non-users were matched by age, sex, and date of the initial antidepressant treatment. Antidepressants classified as N06A in the WHO Anatomical Therapeutic Chemical Classification System were selected. The primary endpoint was the first occurrence of stroke within 180 days of the initial antidepressant treatment. Results: Antidepressant use was associated with an increased risk of stroke (HR, 4.33; 95% CI 2.30-8.14). Similar results have also been found among users of TCA and SARI, but there was no significant risk among users of SSRI and SNRI. Among patients without psychiatric disorders (HR, 5.47; 95% CI, 2.58-11.61) or neurological disorders (HR, 4.10; 95% CI, 2.12-7.95), antidepressant users had a significantly higher risk of stroke than non-users. Conclusions: The indication for antidepressants should be carefully assessed within 6 months of the initial treatment to avoid stroke risk, particularly in adults aged 18-44 years. When antidepressants are first indicated, SSRI and SNRI may be safer options.