Management of Unintentional Acute Organophosphate Poisoning After Dermal Exposure in Primary Health Care Setting: A Rare Case ReportBishal Koirala1, Priyanka Devkota2, Raghu Devkota31Medical Officer, Dangisharan Basic Hospital, Dang, 22400, NepalEmail: bishalkoirala22@gmail.comORCiD: 0009-0008-3663-997XContact number: +97798455675411Corresponding Author2Lab Research Analyst, Duke Human Vaccine Institute, North Carolina, 27710, USAEmail: pd167@duke.eduORCiD: 0009-0003-4882-114XContact number: +166249702363GP Registrar, Clocktower medical centre, Sale, Victoria, 3850, AustraliaEmail: rndevkota90@gmail.comContact number: +61431407427

Avian pathogenic Escherichia coli (APEC) poses significant health risks in poultry, leading to infections that impact productivity. APEC strains exhibit antibiotic resistance, complicating treatment options. Current vaccination strategies are limited in their protective scope, necessitating the exploration of innovative alternatives such as probiotics, bacteriophages, immune stimulants, and antimicrobial peptides (AMPs). AMPs show promise due to their rapid action against resistant bacteria and minimal resistance development. Additionally, small molecules have demonstrated effectiveness against various APEC serotypes, supporting the development of new antimicrobial therapies. Overall, a multifaceted approach addressing APEC’s virulence factors and incorporating novel therapies is crucial for controlling colibacillosis in poultry and mitigating risks to human health.

Dapsone Hypersensitivity Syndrome with Hepatic Involvement: A Rare Case ReportBishal Koirala (Corresponding Author), Medical Officer, Shreegaun Primary Health Centre, Dang, NepalEmail: bishalkoirala22@gmail.comContact number: +9779845567541Priyanka Devkota, Lab Research Analyst, Duke Human Vaccine Institute, North Carolina, USAEmail: priyankadevkota0@gmail.comContact number: +16624970236

A document by Shritik Devkota. Click on the document to view its contents.