An method for the electrochemical synthesis of chalcogenosulfonates via a tandem multi-component reaction has been developed. This method is performed in an undivided cell without the requirement of external oxidants, acids, and transition metals. A variety of indoles and sulfinic acid sodium salts can be used in this method, and it is effective for the late-stage modifications of complex molecules. Not only thiosulfonates and selenosulfonates but also sulfonotelluroates could be prepared, making this protocol a useful tool for the devel-opment of new functional molecules. The afforded products are promising for pesticide development.