High risk PFO-associated stroke: Proposed algorithm for better risk stratificationPetronela Cristina Chiriac1†, PhD, Anca Dumitrescu Bordianu2†, MD, Mariana Floria 1,3, MD, PhD1 Internal Medicine Clinic, ”Sf. Spiridon” Emergency Clinical Hospital Iasi, 700111, Romania.2 Vascular Surgery Clinic, ”Sf. Spiridon” Emergency Clinical Hospital Iași, 700111, Iasi, Romania.3 Faculty of Medicine, Department of Internal Medicine, University of Medicine and Pharmacy ”Grigore T. Popa”, 700111 Iasi, Romania.† Both authors contributed equally.Running title: PFO-associated strokePetronela Cristina Chiriac: chiriac.cristina@spitalspiridon.ro;Anca Dumitrescu Bordianu: bordianu.anca@d.umfiasi.ro;Mariana Floria: floria.mariana@umfiasi.ro; https://orcid.org/0000-0002-9465-1503Correspondence : Floria Mariana, Internal Medicine Department, Grigore T. Popa” University of Medicine and Pharmacy, 16th University Iași, 700115, Romania. E-mail: floria.mariana@umfiasi.ro; floria_mariana@yahoo.com

Patent foramen oval and ESUS in cryptogenic stroke: still a complex puzzleDiana-Elena Iov1,2, MD, Mariana Floria1,3*, MD, PhD, Daniela Maria Tanase1,3, MD, PhD1Faculty of Medicine, Department of Internal Medicine, University of Medicine and Pharmacy ”Grigore T. Popa”, 700111 Iasi, Romania.2Emergency Clinical Hospital ”Saint Spiridon”, Institute of Gastroenterology and Hepatology, 700111 Iasi, Romania.3Emergency Clinical Hospital ”Saint Spiridon”, Internal Medicine Clinic, 700111 Iasi, Romania.Running title: Patent foramen oval related stroke