In France, the abuse/misuse of psychoactive substances, including cocaine, is monitored via spontaneous notifications, and under-reporting is its main limitation. Therefore, the French national hospital discharge database (PMSI) was used to identify all hospital stays possibly due to complications related to cocaine use. Hospitalizations for cocaine-related complications increased by 4-fold between 2010 and 2019. This increase was similar in men and women, and was observed in each age category. Patients were mainly men, with a median age of 38.5 and 35.2 years for men and women, respectively, in 2019. Cocaine poisoning in pediatric patients (0-9 years) concerned less than 10 patients in 2010 and 21 patients in 2019. PMSI data analysis shows an overall increase of cocaine-related hospitalizations that can be linked in part to an increasing recreational use. The increase of pediatric cases of cocaine poisoning suggest a trivialization of these cocaine consumption.