Purpose: To evaluate the prognostic value of left ventricular global index and myocardial contraction fraction based on 2D echocardiography results in patients with coronary artery disease. Materials and methods: Patients with coronary artery disease, confirmed by coronary angiography and ventriculography, were included in the prospective clinical study. 30 patients without coronary artery disease were a control group, 35 patients had monovascular lesions or non-stenosing atherosclerosis, 66 had multivessel coronary artery disease. Left ventricular global index and myocardial contraction fraction were calculated using 2D echocardiography technique. Results: The groups were comparable in age, body mass index and comorbidities. The mean age of patients in group I was 60.53±1.77 years. In group II, the average age was the highest – 64.31±1.62 years, and in group III the participants were 63.0±1.14 years old. The data indicate the absence of a significant difference (p = 0.39) in the age structure of patients. The control group was dominated by women (70%), compared to groups II and III, where the proportion of women was 31.2% and 21.2%, respectively (p = 0.0001). The highest body mass index, classified as obesity class 1, was observed in the first group – 31.74 ± 1.09 kg/m 2. Group III had body mass index of 30.71 ± 0.62 kg/m 2, which also indicates obesity class 1. Group II had the lowest body mass index – 29.76 ± 0.77 kg/m 2, but the difference between the groups was insignificant (p = 0.432). Left Ventricular Global Index and Myocardial Contraction Fraction differed significantly among groups (р=0.003 and р=0.004 respectively). Myocardial Contraction Fraction was the highest in patients with multivessel disease – 35.0 (27.71; 42.0) %, and the lowest in the group with no vascular lesions – 42.29 (36.35; 52.21) %. Left Ventricular Global Index also was different among the groups. It was the lowest in group III – 24.91(19.22; 30.48) %, and the highest in group I – 30.85 (25.46; 37.13) %. Conclusions: myocardial contraction fraction and left ventricular global index are closely related to the degree of coronary artery involvement.