Rationale, aims and objectives: Rasmussen’s encephalitis (RE) is a sporadic and progressive neurological disorder which affects mostly children or young adults. Despite RE is considered a typically childhood disease, it can also affect adulthood. RE patients quality of life (QoL) is bound to worsen because of frequent seizures and due to neurological deficits that cause progressive deterioration but the evaluation of QoL seems to be underestimated in literature. The study aims to explore QoL such as the health conditions of RE young/adult patients that underwent treatment at Fondazione IRCCS Istituto Neurologico Carlo Besta throughout narrative medicine. This would provide an opportunity for healthcare providers to identify the main difficulties and to manage and improve nursing care planning. Method: Audio-recorded, semi-structured interview was performed. During the interview, patients were able to describe their experience throughout the illness narratives. The verbatim transcribed interviews were analyzed according to principles of narrative medicine. Results: We analyzed 13 patients. Overall 11 patients were excluded and two were enrolled in the study. We performed thematic analysis and content analysis of the interviews. It emerged how there are circumstances/factors that influence patients’ lives, such as physical factors, psychological factors, environmental factors, socio-cultural factors and political and economic factors. Conclusion: Narratives of RE patients, allowed us to explore aspects of their lives that are not usually taken into consideration in the daily clinical practice: the need for support, the absence of a social support such as network and the need and the desire to feel and remain active and involved in work and social environment. Adult-onset ER is a very rare disease that significantly interferes with QoL both of patients and caregivers. The attempt to identify all the possible strategies that can facilitate the patient’s adaptation on work and social environment is worth every effort.