This article addresses the problem of global practical output tracking by output feedback for a class of uncertain inherently time-varying delay nonlinear systems. Firstly, a homogeneous output-feedback controller is designed for the nominal uncertain inherently system by virtue of adding a power integrator technique. Then, with the help of an appropriate Lyapunov-Krasovskii functional and reduced-order observer, by using homogeneous domination approach and the adding a power integrator method, an output feedback controller is successfully developed to guarantee all the states of the closed-loop system remain to be bounded and simultaneous make the tracking error arbitrarily small. The simulation results of an example verify the proposed approach