Background: Pulmonary vein isolation (PVI) has been the mainstay of catheter ablation for atrial fibrillation. Left atrial sphericity (LASP) was proposed as a new predictor of AF recurrence following ablation. While, evidence supporting this theory is conflicting. Objective: To clarify whether LASP is associated with increased risk of AF recurrence post PVI through a systematic review and meta-analysis. Methods: All studies evaluating the association between LASP and AF recurrence post-PVI were included by searching PubMed, Web of Science, Cochrane library, EMBASE and CNKI until August 1st, 2021. Two investigators performed screening, data extraction and quality assessment of the studies independently. Results: Ten articles with a total of 1608 patients were finally included. Results were presented as odds ratio (OR) with 95% confidence intervals (CI) and a random model was used. Higher LASP increases the risk of AF recurrence post PVI (HR =1.08, 95% CI1.02-1.14). Sub-group analysis showed that different modalities of measuring LASP (MRI and CT) had no significant impact on the odds. Funnel plot (Begg’s test, P=0.043) showed publication bias. Conclusion: LASP is associated with increased risk of AF recurrence post PVI