Objective: This study was conducted to examine the effects of red cell distribution width (RDW) as prognostic criterion in severe burns. Method: The study is a descriptive correlational study, and carried out retrospectively. Patients with high RDW and low albumin values among severe burn injuries in the burn unit of a university hospital constituted half of the sample. Severe burns with RDW within normal range and a prognostic criterion which Albumin level normal and closest to normal accounted for the other half (n=120). RDW and albumin values were compared with the clinical results of patients with severe burns. IBM SPSS (Statistical Package for the Social Sciences) Statistics 25 was used for data analysis. Results: Of the burn patients, 38.33% were between the ages of 65-80, 51.67% were men, and 92.5% had third-degree burns. The mean albumin level of the patients was 2.39±0.34 g/dL, and the mean RDW level was 18.47±6.15%. The length of the stay in the intensive care unit was 13.45±7.83 days, and the duration of central venous catheter use was 23.41±8.25 days. High RDW and low albumin values were found to be associated with death, length of stay in the intensive care unit and more blood transfusion. Conclusion: High RDW and hypoalbuminemia significantly affect the clinical results of severe burns. Both parameters are effective in determining the clinical course of burn patients, the length of hospital stay, presence of catheters and medication treatment protocol.