Background: Study showed that a lower PVC burden originating from the right ventricle was able to decrease left ventricular function compared to PVC burden originating from the left ventricle (≥10% vs ≥20%). In addition, animal studies have shown differences in the degree of fibrosis due to arrhythmias in the left ventricle compared to the right ventricle. Objective: evaluate the association between location of VOT arrhythmia to intrinsic left ventricular systolic function in patient without structural heart disease Methods: This is a cross-sectional study in 36 ventricular outflow tract arrhythmia patients assessed by V2QRSi40 electrocardiogram criteria with PVC burden ≥4% in National Cardiovascular Center Harapan Kita (NCCHK) from February 2021 to May 2021. Intrinsic left ventricular systolic function assessed by global longitudinal strain (GLS) with speckle tracking echocardiography (STE). Statistical analysis was conducted to evaluate the association between origin of VOT (right VOT vs left VOT) and GLS. Results: Of the 36 subjects, the proportion of female sex was higher than that of men (72.2% versus 27.8%), with the mean GLS score in women being higher than in men (–20,5±4,3 vs. -17,7±3,3, p=0.072). Patients with non-sustained VT episodes had a lower mean GLS score than those without (-15,5±3,1 versus -20,6±4,0, p<0.05). The location of the ventricular outflow arrhythmias was not associated with GLS values either by bivariate analysis or multivariate analysis [p=0,843; coefficient B (CI95%) = -0,036 (-3,441 - 2,832)]. Conclusion: Location of VOT arrhythmia was not associated with intrinsic left ventricular systolic function in patient without structural heart disease