Introduction: Patients who have had a nephrectomy usually have a previous history of renal dysfunction or are at risk for kidney failure due to tissue loss during surgery. In this study, we aimed to retrospectively evaluate the factors affecting acute renal function in nephrectomy surgeries under sevoflurane anesthesia. Method: Demographic data of patients, case type, surgery type, duration of anesthesia, intraoperative lactate level, and postoperative complications of patients who underwent nephrectomy in our clinic were reviewed. Renal function was compared with the levels of urea, creatinine and estimated glomerular filtration rate (eGFR) in the preoperative (2 day before surgery) and postoperative period (day 2). Results: The mean age of the patients 58.2 ± 13.02, duration of anesthesia 166.24 ± 53.01/min, pre-operative eGFR 84.71 (67.69-90.0), and postoperative eGFR 65.09 (47.91-87.44) were respectively. When the pre- and postoperative renal functions of the patients were compared, the statistically significant results were those of urea (p: 0.01), creatinine (p:0.01), and GFR (p:0.01). The factors affecting GFR decrease were age (p:0.01) and case type (p:0.01). Conclusion: The incidence of acute renal failure is increasing in nephrectomy surgeries, especially in radical ones. Age and case type are effective in causing eGFR decrease.