Objectives To compare a type 2 diabetes mellitus (T2DM) management clinical guideline from the Caribbean to a selection developed nationally and internationally by agencies/organisations. Methods Seven T2DM management clinical guidelines were selected a priori as a sample of international and high-income country-specific clinical guidelines and compared to the country-specific T2DM management clinical guideline from the Caribbean. Two reviewers independently assessed the content (using a previously piloted data extraction form) and quality using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool. Results The Caribbean clinical guideline was found to contain similar levels of T2DM management topics compared to international and high-income country-specific clinical guidelines; however, one country-specific clinical guideline from New Zealand was found to have a substantially lower level of content. The clinical guideline from the Caribbean was found to have low-quality and could not be used in practice; however, only three comparator clinical guidelines were found to have a high-quality and could be recommended for use in clinical practice. A further three comparator clinical guidelines could be used in practice with minor modifications. Conclusion Although the T2DM management clinical guideline from the Caribbean contained a high level of content with regards to relevant topics, it was of insufficient quality to be used in clinical practice. Therefore, an alternative high-quality clinical guideline as identified within this study should be adopted and used within the Caribbean to manage T2DM until a high-quality region-specific clinical guideline is developed.