Granulocytic sarcoma (GS) is a soft mass formed by immature myeloid cells invading extramedullary tissues and organs, which is common in myeloid leukemia. In this case, a two years and four months girl diagnosed with acute myeloid leukemia showed intracranial lesion with right occipital bone involvement on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Follow-up CT showed that the mass had disappeared after chemotherapy. As intracranial GS is difficult to diagnose accurately, early detection and treatment is vital for good prognosis. GS should be part of differential diagnosis when patients with acute myelogenous leukemia showed intracranial soft mass.