Objective Various direct and indirect mechanisms by which glucocorticoid excess and elevated adrenocorticotropic hormone (ACTH) levels impair bone metabolism have been described. In the literature, there are different factors described which affect the early outcome of pituitary surgery in patients with Cushing’s Disease (CD) including preoperative ACTH levels and the clinical severity of the disease. We aimed to investigate the association of BMD Z-scores as a direct indicator of severity of GC excess with the early postoperative remission rate and clinical parameters of the patients with CD. Method Patients diagnosed with CD were retrospectively evaluated. After the exclusion of 230 patients, a final cohort of 87 CD patients were included. Results No significant association was found between DXA results and early postoperative remission. A significant negative correlation between preoperative morning cortisol level and BMD, T-score and Z-score of FT was shown, while there was a positive correlation between preoperative ACTH/Cortisol ratio and DXA results of L1-4. Conclusions This is the first study which investigates if the severity of bone loss is a predictive risk factor for the failure of transsphenoidal surgery for Cushing’s disease and there was no statistically significant relationship between these two entities.