Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with the main clinical characteristics of multi-system and multi-organ involvement of the whole body. It is commonly seen in skin mucosa, skeletal muscle, and respiratory system while rarely involved the spleen. The etiology of SLE is complex and related to many factors such as genetics, sex hormones, and environment. In this case, we present a young female patient with SLE with the symptom of progressing splenic calcification.