Despite its importance to the functioning of Entrepreneurial Ecosystems (EEs), the orchestration of networks remains a largely undertheorized topic. To address this omissio, we sought to explain the interplay between networks, their orchestrators, and their implications for ecosystem outcomes. To do so, we conducted an in-depth case study of the Agtech Valley in Brazil. This has led us to develop theoretical insights on the notion of ‘ecosystem coherence’ as a foundational driver of EE structuration. Findings revealed two dimensions of EE coherence: capabilities coherence (based on organizational and cognitive proximities) and relationship coherence (based on institutional and social proximities).