Background: Catheter ablation (CA) and left atrial appendage occlusion (LAAO) are commonly performed minimally invasive procedures for atrial fibrillation. Takotsubo syndrome (TTS), typically induced by severe emotional or physical stressors, is seldom observed as a consequence of these minor surgeries. Methods and Results: We reported a rare case of TTS resulting in significant ST-segment alterations and ventricular tachycardia following a one-stage intervention combining CA and LAAO. Conclusion: This case serves as a reminder that physicians should recognize the risk of iatrogenic TTS in intervention procedures. Timely diagnosis and appropriate supportive therapy can mitigate adverse outcomes and ensure a positive patient prognosis.