loading page

Determinants of Immunoglobulin G responses to respiratory viruses in children and adults
  • +15
  • Alicia Guillien,
  • Katarzyna Niespodziana,
  • Marion Mauclin,
  • Anne Boudier,
  • Raphaëlle Varraso,
  • Benedicte Leynaert,
  • Orianne Dumas,
  • Nicole Le Moual,
  • Thomas Schlederer,
  • Maja Bajic,
  • Kristina Borochova,
  • Peter Errhalt,
  • Raphael Vernet,
  • Rachel Nadif,
  • Jean Bousquet,
  • Emmanuelle Bouzigon,
  • Rudolf Valenta,
  • Valérie SIROUX
Alicia Guillien
Institut pour l'Avancee des Biosciences

Corresponding Author:alicia.guillien@univ-grenoble-alpes.fr

Author Profile
Katarzyna Niespodziana
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
Author Profile
Marion Mauclin
Institut pour l'Avancee des Biosciences
Author Profile
Anne Boudier
Institut pour l'Avancee des Biosciences
Author Profile
Raphaëlle Varraso
Universite Paris-Saclay Bibliotheques Universitaires
Author Profile
Benedicte Leynaert
Universite Paris-Saclay Bibliotheques Universitaires
Author Profile
Orianne Dumas
Universite Paris-Saclay Bibliotheques Universitaires
Author Profile
Nicole Le Moual
Universite Paris-Saclay Bibliotheques Universitaires
Author Profile
Thomas Schlederer
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
Author Profile
Maja Bajic
Karl Landsteiner Gesellschaft
Author Profile
Kristina Borochova
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
Author Profile
Peter Errhalt
Karl Landsteiner Gesellschaft
Author Profile
Raphael Vernet
Universite Paris Cite Faculte de Sante
Author Profile
Rachel Nadif
Universite Paris-Saclay Bibliotheques Universitaires
Author Profile
Jean Bousquet
Universite Paris-Saclay Bibliotheques Universitaires
Author Profile
Emmanuelle Bouzigon
Universite Paris Cite Faculte de Sante
Author Profile
Rudolf Valenta
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
Author Profile
Valérie SIROUX
Institut pour l'Avancee des Biosciences
Author Profile

Abstract

Introduction: Exposure to respiratory viruses is a significant cause of morbidity and affects virus-specific antibody levels. Little is known about determinants associated with immune response to these viruses. We aimed to investigate the determinants of respiratory syncytial virus (RSV) and rhinovirus (RV) specific IgG responses in both children and adults. Methods: The study is based on the EGEA cohort, composed of 530 samples of children in EGEA1 (1991-95) and 1241 samples of adults in EGEA2 (2003-07). Cumulative RV-specific IgG responses (species A, B and C) and IgG responses to RSV-G protein were measured by micro-array technology. Multiple linear mixed models (random effect to account for familial dependence) were performed to assess associations between age, sex, body mass index (BMI), tobacco smoke exposure and season of blood sampling with RSV and RV-specific IgG levels. Results: In children (11.1±2.8 years old, 57% of boys), higher RV-specific IgG levels were associated with older age (only for RV-B), female sex and lower BMI, while only older age was associated with higher RSV-specific IgG levels. In adults (43.5±16.7 years old, 48% of men), younger age, female sex, lower BMI, active smoking and all seasons except summer were associated with higher RV-specific IgG levels. Older age, active smoking and all seasons except summer were associated with higher RSV-specific IgG levels. Conclusion: Personal and seasonal determinants of RSV- and RV-specific IgG levels seem to vary according to the respiratory virus type and between children and adults, suggesting different patterns of responses along the life course.