Exactly 9% of the world’s HIV-positive people live in Nigeria. Over 6 million persons with HIV are still reported to live in South Africa. The adult prevalence rate is 26.5% in Swaziland, followed by 17.9%, 13.3%, and 11.1% in South Africa, Namibia, and Mozambique, respectively. South Africa, where females had a three times higher annual incidence than males (1.5% vs 0.5), saw the greatest rate of new HIV infections in 2017 among youths between the ages of 15 and 24 (1% annual incidence). The inadequate access to and rates of HIV testing among teenagers in high HIV burden African countries have been emphasized. An effective Sexual and Reproductive Health Education (SRHE) will go a long way in promoting healthy behaviors and reduce the transmission of HIV and sexually transmitted infections (STI’s). Youth-targeted television shows and other cutting-edge Comprehensive Sexuality Education (CSE) programs have been successful in giving young people the knowledge and skills they need to protect themselves and make responsible sexual health decisions. However, important obstacles such as societal hurdles, educator resistance, and gender inequities continue to exist. A multidimensional strategy, including thorough curricula, teacher training, peer education, coordination with healthcare providers, community participation, and family involvement, is needed to overcome these barriers.