Introduction:Sebaceous cysts, often known as epidermoid cysts, are keratin-containing unilocular retention cysts. It frequently appears on the head, neck, scalp, scrotum, earlobe, and breast, and can range in size from a few millimetres to less than a few centimetres. When an epidermal cyst exceeds more than 5 cm in diameter, it is considered a giant cyst. The development of cancer is more likely in giant epidermal cysts, which are uncommon.1Conventional sebaceous cysts are typically small, slowly expanding, non-sensitive lesions with a dome shape. Unless it becomes infected or enlarges to the point where it damages nearby anatomical structures, an epidermal cyst is typically asymptomatic. Authors have previously described enormous epidermal cysts with diameters greater than 5 cm.2,3A well-developed granular cell layer lines epidermoid cysts, which are also lined by stratified squamous epithelium. On rare occasions, the cyst wall may also contain pseudostratified ciliated columnar epithelium. The cyst wall may have calcification of a dystrophic type. The preferred course of action is excision. Studying the occurrence of enormous sebaceous cysts was the goal.4Epidermal inclusion cysts, ganglion cysts, neurogenic tumors, myxoid tumors, nodular fasciitis, and dermatofibrosarcoma protuberans are among the possible diagnoses. The reported incidence of malignant degeneration to squamous-cell carcinoma is 2.2%. 5The present study reported a case of a giant sebaceous cyst over the posterior upper back in a 75-year-old male.