The organic peroxide industry is highly hindered by accidents resulting from their synthetic reaction. It is significant demand for green advances to develop efficient & safe synthesis technology for methyl ethyl ketone peroxide (MEKPO) and other organic peroxides. Moreover, lacking quantitative model for MEKPO synthesis reaction, it is insufficient to determine regulatory mechanism, eliminate potential risks, and achieve successful scale-up. Herein, a microreaction platform was established to get thermodynamics and apparent kinetics model of MEKPO synthesis reaction. With its guidance, a scaled-up microreaction process was developed for such a typical organic peroxide (MEKPO), with 1000 tons/year productivity. In the pilot plant, the conversion of reactants is higher than current batch process, within only 390s residence time. The space-time yield increased by 55 times, which greatly reduced the liquid hold-up and ensured safety. It is the first microreaction pilot plant for organic peroxides, improving both safety and efficiency for the industry.