Introduction Nasal packs are indispensable to nasal surgeries. The primary function of these packs is to modulate the bleeding, prevent adhesions and obstruction, with least discomfort to the subjects without risking secondary infection. However, both packing and removal of the pack is an unpleasant experience, with the latter being extremely painful. Therefore, to overcome the limitation of the standard dressing, the need of the hour is a dressing which prioritizes subject comfort without compromising other desired nasal pack properties. Methods Twenty subjects were enrolled in this interventional, open label study. The subjects had 10 hospital visits, starting from baseline (Visit 1) to postoperative day 28 (Visit 10), at regular intervals. The proportion of the population with postoperative pain alleviation and bleeding control failure (within 10 minutes) were the main objectives. Result Within 10 minutes of VELNEZ administration, all 20 participants got their bleeding under control. With VELNEZ, the painful nasal pack removal method was totally avoided because it was biodegradable. No moderate/severe pain, infection and adhesions were reported in any of the subjects, but few subjects reported moderate obstruction until Visit 3 (Discharge Day). Conclusion In the present study, for participants undergoing nasal surgery, VELNEZ proved to be a secure and reliable nasal pack.